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Table 2 Changes in serum urate and plasma oxypurinol between R+ groups

From: How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

  R+ ≤ 100 mg (n = 38) R+  101-200 mg (n = 46) R+ > 200 mg (n = 48) P
SU < 6 mg/dl, n (%) 27 (71.1) 38 (82.6) 37 (77.1) 0.45
Mean SU, mg/dl (mean (SEM)) 5.7 (0.18) 5.3 (0.11) 5.5 (0.17) 0.19
Percentage change in SU −2.5 (4.3) −19.0 (2.4) −23.6 (3.1) < 0.001
Delta SU, mg/dl, mean (SEM) −0.35 (0.23) −1.4 (0.20) −1.95 (0.26) < 0.001
Plasma oxypurinol (umol/l) mean, (SEM) 92.8 (9.8) 151.3 (11.9) 185.1 (16.9) < 0.001
  1. R+ amount of allopurinol (milligrams) above creatinine clearance-based dose, SU serum urate