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Table 2 Changes in serum urate and plasma oxypurinol between R+ groups

From: How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

 

R+ ≤ 100 mg (n = 38)

R+  101-200 mg (n = 46)

R+ > 200 mg (n = 48)

P

SU < 6 mg/dl, n (%)

27 (71.1)

38 (82.6)

37 (77.1)

0.45

Mean SU, mg/dl (mean (SEM))

5.7 (0.18)

5.3 (0.11)

5.5 (0.17)

0.19

Percentage change in SU

−2.5 (4.3)

−19.0 (2.4)

−23.6 (3.1)

< 0.001

Delta SU, mg/dl, mean (SEM)

−0.35 (0.23)

−1.4 (0.20)

−1.95 (0.26)

< 0.001

Plasma oxypurinol (umol/l) mean, (SEM)

92.8 (9.8)

151.3 (11.9)

185.1 (16.9)

< 0.001

  1. R+ amount of allopurinol (milligrams) above creatinine clearance-based dose, SU serum urate