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Table 4 Details of the nine participants who died during the dose escalation phase of the study

From: How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

Month of death Baseline allopurinol dose Allopurinol dose at death R+ (mg/day) Baseline CrCL (ml/min) Urate (mmol/l) at visit preceding death Oxypurinol (μmol/l) at visit preceding death Cause of death
11 200 400 + 300 28 0.34 341 Heart failure
11 300 400 + 250 32 0.37 64 Lung infection
3 200 250 + 100 37 0.45 205 Heart failure
9 600 400 + 150 84 0.64 0 Acute coronary syndrome
5 150 250 + 50 65 0.37 288 Heart failure
10 300 300 + 150 46 0.40 201 Cardiac arrest
9 200 250 + 150 31 0.4 164 Heart failure
4 600 600 + 400 56 0.46 179 Aortic dissection
2 300 300 + 100 51 0.40 139 Heart failure
  1. R+ amount of allopurinol (milligrams) above creatinine clearance-based dose