How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

Table 4 Details of the nine participants who died during the dose escalation phase of the study

Month of death	Baseline allopurinol dose	Allopurinol dose at death	R+ (mg/day)	Baseline CrCL (ml/min)	Urate (mmol/l) at visit preceding death	Oxypurinol (μmol/l) at visit preceding death	Cause of death
11	200	400	+ 300	28	0.34	341	Heart failure
11	300	400	+ 250	32	0.37	64	Lung infection
3	200	250	+ 100	37	0.45	205	Heart failure
9	600	400	+ 150	84	0.64	0	Acute coronary syndrome
5	150	250	+ 50	65	0.37	288	Heart failure
10	300	300	+ 150	46	0.40	201	Cardiac arrest
9	200	250	+ 150	31	0.4	164	Heart failure
4	600	600	+ 400	56	0.46	179	Aortic dissection
2	300	300	+ 100	51	0.40	139	Heart failure

ISSN: 1478-6362