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Table 5 Regression analysis of variables associated with carotid wall volume in patients with RA

From: Carotid artery volumetric measures associate with clinical ten-year cardiovascular (CV) risk scores and individual traditional CV risk factors in rheumatoid arthritis; a carotid-MRI feasibility study

Variable Carotid wall volume (ul)
Univariable analysis (n = 60, unless otherwise stated) Multivariable analysisb
R2 = 0.250, n = 60
Correlation coefficient B (95% CI) P value B (95% CI) P value
Agea 0.35 1.63 (0.47, 2.79) 0.007 1.13 (0.32, 1.93) 0.007
Male gendera 0.25 24.49 (0.01, 48.98) 0.050 15.99 (−10.62, 42.60) 0.234
Systolic blood pressure 0.13 0.28 (−0.29, 0.85) 0.329
Ever smoked 0.33 29.71 (7.26, 52.16) 0.010 19.43 (−1.48, 40.34) 0.068
Body mass index −0.09 −1.16 (−4.66, 2.34) 0.508
Waist/hip circumference 0.18 100.40 (−43.20, 244.001) (n = 58) 0.167
TC/HDL-C −0.07 −2.92 (−14.74, 8.90) (n = 57) 0.622
HOMA-IR 0.09 1.66 (−0.61, 3.93)b (n = 56)c 0.523
NT-proBNP −0.09 −0.08 (− 0.33, 0.16) (n = 56) 0.499
RA disease duration 0.31 1.36 (0.25, 2.46) 0.017 0.78 (−0.24, 1.79) 0.131
3-variable DAS28 −0.021 −0.75 (− 10.07, 8.57) 0.872
ACPA 0077 8.58 (−21.004, 38.18) (n = 59) 0.564
HAQ-DI 0.07 3.78 (− 11.98, 19.54) (n = 57) 0.633
History of joint surgery −0.02 −1.76 (−27.45, 23.94) 0.892
Current use of biological DMARD −0.02 −1.582 (−25.84, 23.79) 0.905
  1. ACPA anti-citrullinated peptide antibody, CI confidence intervals, CRP C-reactive protein, DAS28 28-joint disease activity score, DMARD disease-modifying anti-rheumatic drug, HAQ-DI Health Assessment Questionnaire-Disability Index, HOMA-IR homeostasis model of assessment of insulin resistance, MWT mean wall thickness, NT-proBNP N-terminal pro-brain natriuretic peptide, TC/HDL-C total cholesterol/high-density lipoprotein cholesterol ratio
  2. aVariable entered into linear regression model as associated with carotid wall volume in the literature
  3. bHeteroskedasticity of residuals therefore robust standard errors employed to compensate
  4. cExcluding high outlier: correlation coefficient − 0.07 B (95% CI) − 3.82 (− 15.45, 7.82) p = 0.513