Table 4 Prognostic factors of childhood Takayasu’s arteritis (c-TA) in univariable Cox regression analysis
Factors | Event | Vascular complication | Flare | Rehospitalization | ||||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
BMI | 0.50 (0.31–0.82) | 0.006 | 0.56 (0.35–0.89) | 0.015 | 0.44 (0.23–0.84) | 0.01 | 0.83 (0.51–1.34) | 0.44 |
Age at admission | 0.93 (0.82–1.06) | 0.28 | 0.94 (0.83–1.07) | 0.32 | 0.96 (0.83–1.12) | 0.64 | 0.86 (0.75–0.98) | 0.03 |
Male sex | 0.91 (0.44–1.91) | 0.81 | 1.12 (0.53–2.34) | 0.76 | 0.99 (0.37–2.62) | 0.98 | 1.35 (0.61–2.97) | 0.45 |
Stroke | 6.42 (2.08–18.89) | 0.001 | 1.37 (0.48–3.93) | 0.56 | 2.89 (0.85–9.85) | 0.09 | 1.31 (0.39–4.38) | 0.66 |
Heart failure | 2.04 (1.10–3.82) | 0.03 | 1.56 (0.84–2.90) | 0.16 | 1.46 (0.65–3.27) | 0.36 | 1.88 (0.98–3.60) | 0.06 |
Myocardial ischemia/infarction | 3.06 (0.73–12.87) | 0.13 | 2.96 (0.71–12.40) | 0.14 | 2.22 (0.29–16.74) | 0.44 | 1.32 (0.18–9.71) | 0.78 |
Hypertension | 0.48 (0.26–0.88) | 0.02 | 0.51 (0.28–0.93) | 0.03 | 0.38 (0.18–0.82) | 0.01 | 0.76 (0.38–1.54) | 0.45 |
Renal insufficiency | 0.47 (0.18–1.19) | 0.11 | 0.52 (0.20–1.32) | 0.17 | 0.57 (0.17–1.90) | 0.36 | 0.52 (0.18–1.46) | 0.21 |
Retinopathy | 0.75 (0.40–1.41) | 0.37 | 0.77 (0.41–1.43) | 0.40 | 1.12 (0.52–2.43) | 0.77 | 0.43 (0.21–0.89) | 0.02 |
Steroids | 0.75 (0.37–1.54) | 0.44 | 0.995 (0.49–2.03) | 0.99 | 1.26 (0.48–3.34) | 0.64 | 1.81 (0.70–4.67) | 0.22 |
Immunosuppressant | 0.49 (0.15–1.59) | 0.24 | 0.49 (0.15–1.60) | 0.24 | 0.31 (0.04–2.29) | 0.25 | 0.91 (0.32–2.59) | 0.86 |
Antihypertensive agents | 1.34 (0.67–2.66) | 0.41 | 1.05 (0.54–2.04) | 0.88 | 1.03 (0.43–2.43) | 0.95 | 1.85 (0.77–4.43) | 0.17 |
Antiplatelet drugs | 0.52 (0.27–0.99) | 0.05 | 0.61 (0.32–1.16) | 0.13 | 0.44 (0.20–0.97) | 0.04 | 0.60 (0.30–1.19) | 0.14 |
Revascularization | 0.44 (0.24–0.81) | 0.009 | 0.45 (0.25–0.82) | 0.009 | 0.28 (0.13–0.62) | 0.002 | 0.47 (0.24–0.89) | 0.02 |
Aortic regurgitation | 1.45 (0.67–3.12) | 0.34 | 1.36 (0.63–2.93) | 0.43 | 1.37 (0.52–3.62) | 0.53 | 1.08 (0.45–2.60) | 0.86 |
Ascending aorta involvement | 1.14 (0.48–2.70) | 0.77 | 0.96 (0.40–2.29) | 0.93 | 1.03 (0.35–3.01) | 0.96 | 1.23 (0.54–2.82) | 0.62 |
Aortic arch involvement | 1.57 (0.73–3.41) | 0.25 | 1.32 (0.61–2.85) | 0.48 | 1.00 (0.34–2.92) | 1.00 | 1.52 (0.70–3.33) | 0.29 |
Descending aorta involvement | 1.06 (0.56–1.98) | 0.87 | 1.03 (0.55–1.91) | 0.94 | 1.16 (0.53–2.53) | 0.72 | 1.03 (0.52–2.02) | 0.93 |
Abdominal aorta involvement | 0.58 (0.31–1.10) | 0.09 | 0.53 (0.29–0.99) | 0.05 | 1.15 (0.54–2.46) | 0.71 | 0.92 (0.49–1.75) | 0.80 |
Renal artery involvement | 0.55 (0.30–0.996) | 0.049 | 0.43 (0.24–0.79) | 0.007 | 0.40 (0.19–0.87) | 0.02 | 0.48 (0.25–0.93) | 0.03 |
Coronary artery involvement | 3.05 (1.07–8.74) | 0.04 | 3.16 (1.11–9.00) | 0.03 | 2.73 (0.62–12.03) | 0.18 | 1.65 (0.39–6.96) | 0.50 |
Pulmonary artery involvement | 1.51 (0.67–3.42) | 0.32 | 1.55 (0.68–3.52) | 0.29 | 1.32 (0.46–3.82) | 0.61 | 1.99 (0.90–4.40) | 0.09 |
Type IIb | 1.73 (0.77–3.90) | 0.19 | 2.03 (0.90–4.58) | 0.09 | 3.13 (1.25–7.82) | 0.01 | 1.37 (0.53–3.54) | 0.52 |
Aneurysm | 0.64 (0.23–1.79) | 0.39 | 0.53 (0.19–1.49) | 0.23 | 0.41 (0.10–1.76) | 0.23 | 0.44 (0.13–1.42) | 0.17 |
Vessel wall thickening | 1.52 (0.77–3.00) | 0.23 | 1.29 (0.66–2.51) | 0.46 | 1.36 (0.59–3.14) | 0.47 | 1.59 (0.82–3.09) | 0.17 |
Elevated ESR | 1.28 (0.68–2.43) | 0.44 | 1.21 (0.64–2.29) | 0.55 | 1.98 (0.92–4.31) | 0.08 | 1.26 (0.64–2.47) | 0.50 |
Elevated CRP | 1.92 (1.01–3.64) | 0.047 | 1.86 (1.00–3.47) | 0.05 | 2.09 (0.95–4.58) | 0.07 | 1.96 (1.02–3.79) | 0.04 |