The oncoprotein TBX3 is controlling severity in experimental arthritis

Table 1 Collagen-induced arthritis (CIA) phenotypes in Eae39r congenic and Eae39r2 sub-congenic mice

Disease parameter (phenotype)	Experimental group
Disease parameter (phenotype)	Eae39r congenic (n = 11)	Littermate controls (n = 15)	p value^a	Eae39r2 sub-congenic (n = 10)	Littermate controls (n = 19)	p value^a
Incidence	9/11 (82%)	8/15 (53%)	0.2167	10/10 (100%)	15/19 (79%)	0.2680
Mean max score^b	9.7 ± 1.6	3.9 ± 1.3	0.0041**	8.30 ± 1.14	4.4 ± 0.8	0.0118*
AUC^c	80.8 ± 18	29.7 ± 11.2	0.0120*	67.8 ± 17.6	25.7 ± 7.2	0.0134*
Mean day of disease onset	42.2 ± 2.6	36.3 ± 3.4	0.1942	47.9 ± 3.4	53.6 ± 2.9	0.2529
Number of mice euthanized^d	7/11 (64%)	3/15 (20%)	0.0426*	5/10 (50%)	2/19 (10.5%)	0.0302*

^aData on the incidence and number of mice euthanized were analyzed using the chi-squared test and the other variables were analyzed using the Mann-Whitney U test; *p < 0.05, **p < 0.01
^bMean max score, indicating collagen-induced arthritis severity, is the mean (± SEM) of the maximum score for all affected mice in the group
^cArea under curve (AUC) is the mean (± SEM) of the sum of scores for mice of the corresponding genotype (days 22–63 for Eae39r and days 30–72 for Eae39r2)
^dMice having a score above 10 were euthanized during the experiment as per recommendations of animal welfare authorities

ISSN: 1478-6362