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Table 4 Estimation of MCID estimates in mRSS using HAQ-DI anchor for all participants

From: Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II)

HAQ-DI N Unadjusted mean Effect size
Mean 95% LCL 95% UCL
Overall
 Change ≤ − 0.48 38 − 6.11 − 8.29 − 3.92 − 0.57
 − 0.14 ≥ change > − 0.48 (MCID estimate for improvement) 34 − 3.56 − 6 − 1.12 − 0.33
 − 0.14 < change < 0.14 108 − 2.55 − 3.47 − 1.62 − 0.24
 0.14 ≤ change < 0.48 26 − 0.88 − 2.84 1.07 − 0.08
 Change ≥ 0.48 37 − 1.03 − 3.14 1.09 − 0.10
Diffuse SSc
 Change ≤ − 0.48 29 − 7.97 − 10.41 − 5.52 − 0.83
 − 0.14 ≥ change > − 0.48 (MCID estimate for improvement) 22 − 4.64 − 8.28 − 0.99 − 0.48
 − 0.14 < change < 0.14 54 − 4.8 − 6.23 − 3.36 − 0.50
 0.14 ≤ change < 0.48 16 − 1.69 − 4.88 1.5 − 0.18
 Change ≥ 0.48 25 − 1.48 − 4.56 1.6 − 0.15
Limited SSc
 Change ≤ − 0.48 9 − 0.11 − 2.3 2.08 − 0.03
 − 0.14 ≥ change > − 0.48 (MCID estimate for improvement) 12 − 1.58 − 3.74 0.57 − 0.44
 − 0.14 < change < 0.14 54 − 0.3 − 1.15 0.56 − 0.08
 0.14 ≤ change < 0.48 10 0.4 − 0.68 1.48 0.11
 Change ≥ 0.48 12 − 0.08 − 1.99 1.82 − 0.02
  1. HAQ-DI Health Assessment Questionnaire -Disability Index, LCL lower confidence limit, MCID minimal clinically important difference, mRSS modified Rodnan Skin Score, SSc systemic sclerosis, UCL upper confidence limit