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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

Fig. 5

DZ2002 treatment attenuated glomerulosclerosis in lupus-prone mice. a Representative PAS-stained kidney section (× 400 magnification). b The glomerular tuft area was averaged from all available glomeruli per kidney section to give n = 1, using one kidney section per mouse. c Mesangial matrix fraction was calculated as the ratio of PAS-positive area to total glomerular tuft area and averaged from all available glomeruli per kidney section to give n = 1. Normal, age-matched female C57BL/6 mice; NZB/WF1, vehicle mice in the treatment experiment; and NZB/WF1+DZ2002, DZ2002-treated mice in the treatment experiment. Each dot represented data for individual mouse (n = 7 per group). Data were shown as the mean ± SD. *P < 0.05, ***P < 0.001 versus NZB/WF1 group

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Arthritis Research & Therapy

ISSN: 1478-6362

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