Skip to main content
Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Fig. 6

Intestinal XCR1+CD4− cDCs in B27-Tg rat migrate less in response to TLR-7 stimulation. Low-density cells were isolated from MLN of 6 month-old NTG and B27-Tg rats that had been fed 5 h before with the TLR-7 agonist R-848 to activate DC migration from the intestine to the afferent lymph. Control NTG and B27-Tg rats received PBS. cDCs from MLN were analyzed by flow cytometry. a, b The graphs show the frequency (a) and absolute number (b) of CD4− cDCs among CD103+ cDCs in R-848- and PBS-fed NTG and B27-Tg rats. c The graph shows the ratio of CD4− cDCs number between R848- and PBS-fed conditions in NTG and B27-Tg rats. d, e The graphs show the frequency (d) and absolute number (e) of XCR1+ DCs among CD4− CD103+ cDCs in R-848- and PBS-fed NTG and B27-Tg rats. f The graph shows the ratio of XCR1+ cDCs number between R848- and PBS-fed conditions in NTG and B27-Tg rats. This experiment was repeated 5 times. Bars show the mean ± SEM. Data were analyzed by unpaired Student’s t test

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us