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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells

Fig. 6

Effect of HBO on MAPK phosphorylation. HBO treatment significantly suppressed ERK, JNK, and p38 MAPK phosphorylation in degenerated NPCs. Phosphorylation dot density ratios for the HBO and control groups were determined at 15 and 30 min after the third round of HBO treatment. At 15 min, the ratio for p38 MAPK (*p < 0.05; n = 4) was significantly decreased. At 30 min, the ratio for p38 MAPK (**p < 0.01, n = 4), ERK (*p < 0.05, n = 4), and JNK (*p < 0.05, n = 4) were significantly decreased. These results indicated that HBO treatment significantly suppressed MAPK phosphorylation in degenerated NPCs

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Arthritis Research & Therapy

ISSN: 1478-6362

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