Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain

Table 3 Factors related to SF36-MCS and PCS over 5 to 8 years in early arthritis (EA) and early inflammatory back pain (IBP): results of multivariate mixed linear models, after adjustment on baseline HRQoL

Factors associated with worst HRQoL	MCS beta (p value)	PCS beta (p value)
EA
Age	NS	− 0.0064 (0.010)
DAS28-ESR	NS	+ 0.18 (< 0.001)
Levels of studies	NA	+ 0.26 (0.0001)
DMARDs	NS	+ 0.42 (< 0.001)
Symptom duration	NS	+ 0.0011 (0.048)
Score MCS at baseline	NS	+ 0.013 (< 0.001)
Score PCS at baseline	−0.049 (0.022)	− 0.041 (< 0.001)
Early IBP
ASDAS-CRP	NA	− 0.028 (< 0.001)
Age	NA	− 0.0012 (0.024)
Peripheral arthritis	NS	− 0.025 (0.0078)
TNFi	NA	− 0.028 (0.013)
Score MCS at baseline	−0.0085 (< 0.0001)	+ 0.0018 (< 0.001)
Score PCS at baseline	+ 0.0018 (0.02)	− 0.0055 (< 0.001)

In EA, oral corticosteroid, smoking status and erosions were analyzed for MCS but were not significant. Oral corticosteroid was analysed for PCS but were not significant. In early IBP, female gender, lower symptom duration, studies above high school, presence of enthesitis, no radiological or MRI sacroiliitis were analysed for PCS but were not significant. Intermediate or high level employment were not analysed for PCS and were not significant for MCS. Both analyses were adjusted on baseline HRQoL
DAS28-ESR Disease Activity Score—erythrocyte sedimentation rate, ASDAS-CRP Ankylosing Spondylitis Disease Activity Score—C reactive protein, MCS mental composite score, PCS physical composite score, TNFi tumor necrosis factor inhibitor, NA not analysed (p value > 0.20 in univariate analysis), NS not significant

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