Fig. 5

Biomarker signatures of healthy subjects before and after 17DD-YF vaccination. Biomarker signature analysis was carried out as described previously by Luiza-Silva et al. [14] as described in the “Methods” section. a The biomarker signatures of NV(day0) [white squares] and PV(day30–45) [gray circles] were overlapped as the reference curves, and those biomarkers for which more than 50% of samples were above the cut-off index were selected for further identification of biomarkers upregulated selectively by the 17DD-YF vaccine. b Venn diagram analysis was employed to identify the set of biomarkers selectively increased in the PV(day30–45) group, representing those biomarkers elicited early after 17DD-YF vaccination. These attributes were underscored in a bold font format and selected for further comparative analysis of duration of 17DD-YF-specific responses after vaccination among the study groups