Fig. 1

Upregulation of miR-191 in hypoxic RA-FLS. a HE staining of synovial tissue samples from RA and OA patients. b miRNA profiling analysis for RA-FLS, cultured under normal or hypoxia conditions for 24 h, identified a subset of dysregulated miRNAs. Data was represented as fold change of miRNAs expression in hypoxic RA-FLS, compared to normoxic RA-FLS. c Further validation of the miR-191, miR-297, miR-499b-3p, miR-770, and miR-936 expression in three RA-FLS cells and three OA-FLS cultured under hypoxia condition for 24 h, compared to normoxia condition by quantitative RT-PCR. Data represent results from three independent experiments, shown as means ± SEMs (n = 3, *p < 0.05 by t test)