Table 3 Results of the meta-analysis of prognosis factors in SSc

Age at disease onset (per 1 year)

6

1.05

(1.04–1.07)

68.6

0.007

0.783

Age at diagnosis (per 1 year)

5

1.04

(1.04–1.05)

71.2

0.008

0.025

Male sex

21

1.87

(1.61–2.18)

50.9

0.004

< 0.001

African origin

5

1.38

(1.15–1.66)

25.0

0.255

0.774

dcSSc

23

1.90

(1.62–2.23)

58.3

< 0.001

< 0.001

Anti-Scl70 autoantibodies

13

1.38

(1.09–1.74)

49.6

0.022

0.024

ACA

8

0.62

(0.47–0.82)

56.4

0.025

0.590

Joint involvement

4

1.32

(0.82–2.12)

54.0

0.089

0.508

Renal involvement

9

2.79

(1.95–3.99)

50.9

0.039

0.512

Scleroderma renal crisis

10

3.89

(2.38–6.36)

75.6

< 0.001

0.097

ILD

14

2.34

(1.78–3.08)

69.5

< 0.001

< 0.001

Cardiac involvement

7

4.35

(2.28–8.29)

89.9

< 0.001

0.077

PH (echocardiography

or RHC)

13

3.44

(2.59–4.58)

61.5

0.002

0.057

PH (RHC)

5

5.27

(2.98–9.31)

63.7

0.027

0.761

Cancer

6

2.11

(1.27–3.50)

76.2

< 0.001

0.016