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Table 1 Iguratimod only has weak inhibition on COX-2 activity

From: Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis

Celecoxib Iguratimod
Concentration (M) Inhibition (%) Concentration (M) Inhibition (%)
1.0 × 10−6 97.8 1.0 × 10−6 24.9
   1.0 × 10−7 19.2
   1.0 × 10−8 35.5
   1.0 × 10−9 31.3
  1. The COX-2 inhibition activities of iguratimod or celecoxib was determined with cyclooxygenase products, prostaglandins, which were measured by EIA. At the same concentration (1.0 × 10−6 M), iguratimod exhibited weak inhibition on COX-2 inhibition activity(24.9%), obviously less than celecoxib (97.8%). One representative experiment out of three was shown