Table 2 Characteristics of subjects with and without new digital ulcer (DU) development during follow-up
Patient characteristics at baseline n = 761 | Patients with new DUs (n = 22) | Patients without new DUs (n = 54) | p value | Odds ratio | 95%CI; p value for cut-off |
|---|---|---|---|---|---|
♀: n (%) | 17 (77.3%) | 45 (83.3%) | ns | ||
Mean age in years (± SD) at | |||||
-Enrollment | 56 (± 12.9) | 56 (± 15.0) | ns | ||
-Raynaud’s onset | 43 (± 14.4) | 42 (± 16.4) | ns | ||
-Onset of first non-Raynaud’s symptom | 45 (± 14.7) | 46 (± 15.2) | ns | ||
Smoking | |||||
-Current smokers, n (%) | 5 (22.7%) | 6 (11.1%) | ns | ||
-Mean pack years (± SD) | 13.66 (± 16.38) | 8.040 (± 13.4) | ns | ||
dcSSc, n (%) | 13 (59.1%) | 14 (25.9%) | 0.0087 | 4.1 | 1.5–11.7; p = 0.0087 |
Mean modified Rodnan skin score (± SD) | 13.4 (± 9.4) | 6.7 (± 6.9) | 0.0008 | 9.43 | 3.0–29.2; p < 0.0001 |
ACR/EUSTAR score (± SD) | 19.7 (± 4.0) | 15.6 (± 4.1) | 0.0004 | 8.14 | 2.5–25.6; p = 0.0003 |
-Skin involvement | |||||
-Thickening prox. of MCP, n (%) | 12 (54.5%) | 13 (24.1%) | |||
-Sclerodactyly, n (%) | 9 (40.9%) | 33 (9.1%) | 0.0308 | 3.85 | 1.3-10.8; p = 0.0154 |
-Puffy fingers, n (%) | 1 (4.5%) | 6 (61.1%) | |||
-Sine scleroderma | 0 | 2 (3.7%) | |||
-Digital tip ulcers, n (%) | 16 (72.7%) | 20 (37.0%) | 0.0058 | 4.5 | 1.5–13.5 |
-Pitting scars, n (%) | 18 (81.8%) | 22 (40.7%) | 0.0020 | 6.5 | 1.9–22.0 |
-Teleangiectesia, n (%) | 17 (77.3%) | 43 (79.6%) | ns | ||
-Abnormal capillaroscopy, n (%) | 22 (100%) | 50 (96.2%) | ns | ||
-PAH, n (%) | 6 (27.3%) | 4 (7.8%) | 0.0570 | 4.4 | 1.1–17.6 |
-Interstitial lung disease, n (%) | 10 (45.5%) | 16 (29.6%) | ns | ||
-Raynaud phenomenon, n (%) | 22 (100%) | 54 (100%) | ns | ||
-ACA pos., n (%) | 8 (36.4%) | 17 (31.5%) | ns | ||
-Scl70 pos., n (%) | 9 (40.9%) | 22 (40.7%) | ns | ||
-RNAP III pos., n (%) | 2 (9.1%) | 1 (1.9%) | ns | ||
Medications | |||||
-Iloprost | 14 (63.6%) | 29 (53.7%) | ns | ||
-Bosentan | 6 (27.3%) | 5 (9.3%) | ns | ||
-Oral vasodilators2 | 18 (81.8%) | 32 (59.3%) | ns | ||
Capillaroscopy pattern | |||||
-Early, n (%) | 0 (0%) | 13 (24.1%) | 0.0265 | 18.66 | 1.1-326.4; p = 0.0035 |
-Active, n (%) | 11 (50.0%) | 16 (29.6%) | |||
-Late, n (%) | 11 (50.0%) | 21 (38.9%) | |||
-Non-SSc, n (%) | 0 (0%) | 2 (3.7%) | |||
-Not done, n (%) | 0 (0%) | 2 (3.7%) | |||