Table 2 Causes of treatment discontinuation at 36 months (Cox proportional hazards model, adjusted analysis)
Variable | Reference | HR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|
IFX (n = 748) | ABT (n = 681) | ADA (n = 558) | CZP (n = 229) | ETN (n = 891) | GLM (n = 464) | TCZ (n = 895) | P value | |
Total discontinuation (excluding non-toxic reasons and remission) | 1 | 0.56 (0.46–0.68)*** | 0.99 (0.82–1.20) | 0.96 (0.74–1.23) | 0.92 (0.78–1.08) | 0.71 (0.58–0.88) ** | 0.59 (0.49–0.71)*** | < 0.001 |
Lack of effectiveness | 1 | 0.65 (0.52–0.82)*** | 1.03 (0.82–1.29) | 1.16 (0.87–1.55) | 0.97 (0.80–1.17) | 0.74 (0.57–0.95) ** | 0.54 (0.43–0.67)*** | < 0.001 |
All toxic adverse events | 1 | 0.32 (0.22–0.49)*** | 0.83 (0.58–1.18) | 0.43 (0.24–0.78)** | 0.66 (0.47–0.93)* | 0.57 (0.38–0.85)** | 0.61 (0.43–0.85)** | < 0.001 |
Non-toxic reasons | 1 | 0.92 (0.64–1.34) | 0.98 (0.67–1.42) | 0.40 (0.18–0.87)* | 0.84 (0.60–1.18) | 1.20 (0.83–1.77) | 0.84 (0.60–1.19) | 0.12 |
Remission | 1 | 0.35 (0.20–0.60)*** | 0.98 (0.67–1.44) | 0.80 (0.41–1.56) | 0.40 (0.26–0.60)*** | 0.96 (0.60–1.56) | 0.77 (0.52–1.14) | < 0.001 |