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Table 4 Supra-categories including the biological process gene ontology terms significantly overrepresented when comparing mesenchymal stem cells (MSCs) exposed to activated peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients vs. MSCs exposed to activated PBMCs from RA patients

From: RNA sequencing of mesenchymal stem cells reveals a blocking of differentiation and immunomodulatory activities under inflammatory conditions in rheumatoid arthritis patients

Supra-category

Number of categories in upregulated genes

Number of categories in downregulated genes

Immune system-related

407

2

Signaling-related

89

0

Calcium metabolism-related

53

0

Development-related

50

18

Response to pathogens-related

45

0

Nucleic acids metabolism-related

18

0

Wound repair-related

12

0

Nitric oxide metabolism-related

6

0

Miscellanea

84

6