Primary outcome
|
CPM, mean (SD)a
|
Weeks 0–1
|
0.64 (0.16)
|
0.12 (0.27)
|
0.44 (0.24)
|
0 (0 to 0)
|
.33
|
0 (− 0.31 to 0.32)
|
0.98
|
0.15 (− 0.13 to 0.42)
|
.29
|
Weeks 0–2
|
14.85 (0.16)
|
4.75 (0.28)
|
1.43 (0.24)
|
13.54 (13.23 to 13.85)
|
< .01
|
3.80 (3.45 to 4.15)
|
< .01
|
9.73 (9.44 to 10.02)
|
< .01
|
VAS, mean (SD)b
|
Weeks 0–1
|
− 1.34 (0.10)
|
− 1.52 (0.14)
|
0.65 (0.14)
|
− 0.58 (− 0.71 to − 0.44)
|
< .01
|
− 0.77 (− 0.93 to − 0.62)
|
< .01
|
0.19 (0.04 to 0.35)
|
.01
|
Weeks 0–2
|
− 2.97 (0.10)
|
− 2.75 (0.15)
|
1.19 (0.14)
|
− 1.58 (− 1.75 to − 1.4)
|
< .01
|
− 1.36 (− 1.57 to − 1.16)
|
< .01
|
− 0.22 (− 0.42 to − 0.03)
|
.03
|
WOMAC, mean (SD)c
|
Weeks 0–1
|
− 13.03 (0.56)
|
− 13.06 (0.87)
|
− 3.47 (0.80)
|
− 9.35 (− 10.75 to − 7.96)
|
< .01
|
− 9.66 (− 11.26 to − 8.07)
|
< .01
|
0.18 (− 1.23 to 1.59)
|
.80
|
Weeks 0–2
|
− 20.92 (0.56)
|
− 20.55 (0.89)
|
− 8.87 (0.81)
|
− 11.70 (− 12.52 to − 10.89)
|
< .01
|
− 11.55 (− 12.52 to − 10.58)
|
< .01
|
− 0.15 (− 1.06 to 0.75)
|
.74
|
Secondary outcome
|
NPRS, mean (SD)c
|
Weeks 0–1
|
− 1.59 (0.10)
|
1.12 (0.14)
|
0.72 (0.14)
|
− 0.93 (− 1.1 to − 0.76)
|
< .01
|
− 0.69 (− 0.9 to − 0.49)
|
< .01
|
− 0.11 (− 0.3 to − 0.07)
|
.24
|
Weeks 0–2
|
− 2.97 (0.11)
|
2.48 (0.14)
|
1.40 (0.14)
|
− 1.55 (− 1.76 to − 1.33)
|
< .01
|
− 1.07 (− 1.31 to − 0.83)
|
< .01
|
− 0.47 (− 0.7 to − 0.24)
|
< .01
|
ES, mean (SD)c
|
Weeks 0–1
|
− 1.69 (0.12)
|
− 1.36 (0.16)
|
0.71 (0.13)
|
− 0.91 (− 1.09 to − 0.73)
|
< .01
|
− 0.67 (− 0.88 to − 0.45)
|
< .01
|
− 0.3 (− 0.5 to − 0.1)
|
< .01
|
Weeks 0–2
|
− 3.28 (0.13)
|
− 2.56 (0.16)
|
1.24 (0.13)
|
− 1.88 (− 2.12 to − 1.65)
|
< .01
|
− 1.22 (− 1.49 to − 0.95)
|
< .01
|
− 0.67 (− 0.92 to − 0.42)
|
< .01
|
PPI, mean (SD)c
|
Weeks 0–1
|
− 0.70 (0.07)
|
− 0.68 (0.09)
|
0.29 (0.09)
|
− 0.44 (− 0.58 to − 0.29)
|
< .01
|
− 0.45 (− 0.62 to − 0.28)
|
< .01
|
0.04 (− 0.11 to 0.19)
|
.59
|
Weeks 0–2
|
− 1.46 (0.07)
|
− 1.39 (0.09)
|
0.65 (0.09)
|
− 0.78 (− 0.96 to − 0.6)
|
< .01
|
− 0.82 (− 1.03 to − 0.6)
|
< .01
|
0.04 (− 0.16 to 0.24)
|
.72
|