Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study

Table 1 Clinical characteristics of study participants

	Total sample (n = 266)	With BMLs (n = 94)	Without BMLs (n = 172)	p value
Age, years	54.9 ± 9.6	59.8 ± 7.3	52.3 ± 9.7	< 0.001
BMI, kg/m²	22.2 ± 3.3	22.3 ± 3.3	22.2 ± 3.3	0.886
KOOS
Symptom	94.6 (85.7–100.0)	92.9 (82.1–96.4)	96.4 (89.3–100.0)	0.006
Pain	100.0 (88.9–100.0)	95.8 (82.6–100.0)	100.0 (88.9–100.0)	0.013
ADL short ver.	100.0 (92.9–100.0)	100.0 (85.7–100.0)	100.0 (96.4–100.0)	0.037
QOL	87.5 (73.4–100.0)	81.3 (62.5–95.3)	93.8 (75.0–100.0)	0.004
Symptomatic knee, n (%)	68 (25.6)	34 (36.2)	34 (19.8)	0.003
BMD, g/cm²	0.60 ± 0.09	0.55 ± 0.08	0.62 ± 0.09	< 0.001
BML score	0.0 (0.0–1.0)	1.0 (1.0–2.0)	0.0 (0.0–0.0)	< 0.001

The values represent demographic data of all participants, participants with BMLs, and those without BMLs. Data are presented as mean ± SD for age, BMI, and BMD and median (range) for KOOS and BML score. The data on symptomatic knees is based on the number of participants (percentage of the whole population). Student’s t test was used to compare the mean values of age, BMI, and BMD; Mann-Whitney U test was used to compare the median values of KOOS and BML score, and chi-square test was used to compare the proportions of symptomatic knees between participants with and without BMLs. p value indicates the significance of the difference between participants with and without BMLs
BMI body mass index, KOOS Knee injury and Osteoarthritis Outcome Score, BMD bone mineral density, BMLs bone marrow lesions

ISSN: 1478-6362