Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study

Table 5 Relationships between BMLs and bone markers in participants with asymptomatic knee

With asymptomatic knee (n = 198)	R² (adjusted)	β	p value	95% CI
BAP	0.091	0.167	0.038	0.000 to 0.010
PINP	0.085	0.131	0.087	0.000 to 0.003
NTx	0.075	0.069	0.340	− 0.003 to 0.008
TRACP-5b	0.102	0.228	0.011	0.000 to 0.000
Pentosidine	0.072	0.036	0.623	− 0.001 to 0.002
Homocysteine	0.071	− 0.023	0.742	− 0.010 to 0.007

Statistical analysis—multiple linear regression analysis. Dependent variables—the natural logs of BML score plus 5. Independent variables—age, BMI, and bone markers (BAP, PINP, NTx, TRACP-5b, pentosidine, and homocysteine)
BMLs bone marrow lesions, BAP bone-specific alkaline phosphatase, PINP procollagen type I N-terminal propeptide, NTx crosslinked N-telopeptide of type I collagen, TRACP-5b tartrate-resistant acid phosphatase-5b, R² coefficient of determination, β standardized regression coefficient, CI confidence interval

ISSN: 1478-6362