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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Fig. 5

Evaluation of the ability of different concentrations of F3 to treat collagen-induced arthritis in mice. Arthritis was induced as described above (n = 12 per group), and either F3 (5 or 10 mg/kg) or etanercept (10 mg/kg) was injected intraperitoneally 18 days later (day 0 on graph) before signs of arthritis were evident. Treatments were administered 3×/week (arrows) for a total of 8 doses. a Arthritis scores and body weights were determined every other day. b The study in panel a was repeated except administration of the indicated concentrations of F3 (2×/week; see arrows) was initiated only after arthritis scores reached ~ 2. Error bars represent SEM for all panels

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