Fig. 5
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13075-019-1912-0/MediaObjects/13075_2019_1912_Fig5_HTML.png)
Evaluation of the ability of different concentrations of F3 to treat collagen-induced arthritis in mice. Arthritis was induced as described above (n = 12 per group), and either F3 (5 or 10 mg/kg) or etanercept (10 mg/kg) was injected intraperitoneally 18 days later (day 0 on graph) before signs of arthritis were evident. Treatments were administered 3×/week (arrows) for a total of 8 doses. a Arthritis scores and body weights were determined every other day. b The study in panel a was repeated except administration of the indicated concentrations of F3 (2×/week; see arrows) was initiated only after arthritis scores reached ~ 2. Error bars represent SEM for all panels