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Table 3 Correlations of synovial fluid RBM biomarkers with known osteoarthritis progression biomarkers

From: Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

OA Progression Biomarkers Subset of synovial fluid RBM biomarkers associated with features of knee osteoarthritis*
sVCAM-1
r (95% CI)
(pval)
MMP-3
r (95% CI)
(pval)
sICAM-1
r (95% CI)
(pval)
TIMP-1
r (95% CI)
(pval)
VEGF
r (95% CI)
(pval)
MCP-1
r (95% CI)
(pval)
CD14 0.86 (0.69–0.94)
(< 0.0001)
0.77 (0.50–0.91)
(< 0.0001)
0.84 (0.64–0.94)
(< 0.0001)
0.88 (0.72–0.95)
(< 0.0001)
0.90 (0.76–0.96)
(< 0.0001)
0.50 (0.08–0.76)
(0.016)
CD163 0.80 (0.56–0.92)
(< 0.0001)
0.78 (0.51–0.91)
(< 0.0001)
0.70 (0.37–0.88)
(0.0004)
0.85 (0.66–0.94)
(< 0.0001)
0.75 (0.44–0.90)
(0.0001)
0.43 (− 0.02–0.73)
(0.046)
Neutrophil Elastase 0.88 (0.68–0.96)
(< 0.0001)
0.88 (0.68–0.96)
(< 0.0001)
0.87 (0.64–0.96)
(< 0.0001)
0.89 (0.71–0.97)
(< 0.0001)
0.62 (0.16–0.86)
(0.008)
0.14 (− 0.40–0.61)
(0.581)
  1. *As shown in Table 2; italicized p values pass FDR < 0.05; r = repeated measures correlation coefficient by Bland and Altman method implemented in rmcorr
  2. Abbreviations: RBM Rules Based Medicine, pval p value, CI confidence interval, sVCAM-1 soluble vascular cell adhesion molecule 1, MMP-3 matrix metalloproteinase-3, sICAM-1 soluble intracellular adhesion molecule 1, TIMP-1 tissue inhibitor of metallopeptidase inhibitor 1, VEGF vascular endothelial growth factor, MCP-1 monocyte chemoattractant protein 1