Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

Table 3 Correlations of synovial fluid RBM biomarkers with known osteoarthritis progression biomarkers

OA Progression Biomarkers	Subset of synovial fluid RBM biomarkers associated with features of knee osteoarthritis*
OA Progression Biomarkers	sVCAM-1 r (95% CI) (pval)	MMP-3 r (95% CI) (pval)	sICAM-1 r (95% CI) (pval)	TIMP-1 r (95% CI) (pval)	VEGF r (95% CI) (pval)	MCP-1 r (95% CI) (pval)
CD14	0.86 (0.69–0.94) (< 0.0001)	0.77 (0.50–0.91) (< 0.0001)	0.84 (0.64–0.94) (< 0.0001)	0.88 (0.72–0.95) (< 0.0001)	0.90 (0.76–0.96) (< 0.0001)	0.50 (0.08–0.76) (0.016)
CD163	0.80 (0.56–0.92) (< 0.0001)	0.78 (0.51–0.91) (< 0.0001)	0.70 (0.37–0.88) (0.0004)	0.85 (0.66–0.94) (< 0.0001)	0.75 (0.44–0.90) (0.0001)	0.43 (− 0.02–0.73) (0.046)
Neutrophil Elastase	0.88 (0.68–0.96) (< 0.0001)	0.88 (0.68–0.96) (< 0.0001)	0.87 (0.64–0.96) (< 0.0001)	0.89 (0.71–0.97) (< 0.0001)	0.62 (0.16–0.86) (0.008)	0.14 (− 0.40–0.61) (0.581)

*As shown in Table 2; italicized p values pass FDR < 0.05; r = repeated measures correlation coefficient by Bland and Altman method implemented in rmcorr
Abbreviations: RBM Rules Based Medicine, pval p value, CI confidence interval, sVCAM-1 soluble vascular cell adhesion molecule 1, MMP-3 matrix metalloproteinase-3, sICAM-1 soluble intracellular adhesion molecule 1, TIMP-1 tissue inhibitor of metallopeptidase inhibitor 1, VEGF vascular endothelial growth factor, MCP-1 monocyte chemoattractant protein 1

ISSN: 1478-6362