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Table 2 Changes from Baseline in Primary and Secondary Outcomes Analyses based on the Intention-To-Treat-Population

From: Hand exercise for women with rheumatoid arthritis and decreased hand function: an exploratory randomized controlled trial

  CIPEXERCISE (n=27)
Mean change
(95% CI)
CIPCONTROL (n=27 )
Mean change
(95% CI)
Group difference
Mean change (95%CI)
P-value
AMPSa ADL motor ability 0.24 (0.09 to 0.39) 0.20 (0.05 to 0.35) 0.04 (-0.16 to 0.25) 0.70
AMPSa ADL process ability 0.05 (-0.05 to 0.14) 0.02 (-0.07 to 0.12) 0.02 (-0.11 to 0.16) 0.73
ADL-Questionnaire (ADL-Q) 0.09 (-0.01 to 0.20) 0.09 (-0.02 to 0.19) 0.01 (-0.15 to 0.16) 0.90
HAQ-DIb -0.09 (-0.19 to 0.01) 0.01 (-0.09 to 0.11) -0.1 (-0.24 to 0.04) 0.16
Hand strength and pain
 Max grip strength (Kg)
  Right 1.43 (0.40 to 2.45) 0.18 (-0.86 to 1.23) 1.24 (-0.22 to 2.71) 0.10
  Left 1.00 (-0.47 to 2.47) 0.36 (-0.71 to 3.44) 1.36 (-0.71 to 3.44) 0.20
 Hand pain, Activity (mm VAS
  Right -1.10 (-7.90 to 5.78) 0.57 (-6.27 to 7.41) -1.63 (-11.30 to 8.04) 0.74
  Left -5.26 (-12.80 to 2.28) -0.78 (-8.31 to 6.76) -4.48 (-15.28 to 6.30) 0.41
 Hand pain, Rest (mm VAS)
  Right -1.43 (-8.63 to 5.78) 2.87 (-4.33 to 10.07) -4.30 (-14.49 to 5.00) 0.40
  Left -1.67 (-9.71 to 6.36) 4.41-(-3.62 to 12.45) -6.08 (-17.80 to 5.62) 0.30
PainKillers (Number per day) 0.01 (-0.19 to 0.22) 0.01 (-0.22 to 0.19) 0.02 (-0.26 to 0.31) 0.87
DAS28c -0.17 (-0.49 to 0.15) 0.26 (-0.10 to 0.53) -0.39 (-0.84 to 0.07) 0.09
 Tender joint count -0.51 (-1.83 to 0.82) 0.38 (-0.93 to 1.68) -0.88 (-2.75 to 0.99) 0.35
 Swollen joint count 0.23 (-0.27 to 0.72) 0.15 (-0.33 to 0.63) 0.08 (-0.61 to 0.77) 0.82
 CRPd -0.67 (-2.44-1.11) 1.76 (-0.12-3.63) -2.42 (-5.00-0.15) 0.06
 Disease activity (VAS) -7.97 (-15.86—0.09) -0.70 (-7.93 to 6.53) -7.27 (-17.97 to 3.43) 0.18
ESRe -0.50 (-2.52 to 1.51) 2.30 (0.29 to 4.32) -2.80 (-5.65 to 0.05) 0.05
Ultra Sound (US)
 US score: synovial hypertrophy 0.18 (-2.0 to 2.32) 1.83 (-0.22 to 3.89) -1.66 (-4.63 to 1.32) 0.27
 Synovial perfusion (Doppler) -0.38 (-2.47 to 1.72) 1.01 (-0.99 to 3.03) -1.39 (-4.29 to 1.51) 0.34
 UL score total -1.81 (-5.76 to 2.34) 2.56 (-1.23 to 6.36) -4.37 (-9.86 to 1.11) 0.12
  1. aAMPS Assessment of Motor and Process Skills
  2. bHAQ-DI Stanford Health Assessment Questionnaire Disability Index
  3. cDAS28 Disease Activity Score 28
  4. dCRP C-reactive protein
  5. eESR Erythrocyte Sedimentation Rate
  6. fAntiCCP anti Cyclic Citrullinated Peptides
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