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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts

Fig. 4

Effect of inflammatory factors on activin A and follistatin in RASF. a Activin A protein release was induced by TNFα and to a higher extent IL-1β. The IL-1β-induced activin A level could be reduced by follistatin but not TNFα-induced activin (n = 7 RASF). b Follistatin level was reduced by IL-1β but not other pro-inflammatory stimuli (n = 5 RASF). c IL-6 showed highly individual baseline levels in different patients. IL-6 (n = 6), proMMP-1 (n = 7), or sTNF-RI (n = 4) levels were not induced by more than 2-fold by activin A

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