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Table 1 Isothermal fluorescence values for CCL2, CCL7 and CXCL8 binding to HS and syndecan-3. Isothermal fluorescence values are expressed as dissociation constants (Kd) with standard error of the mean

From: Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis

 

Heparan Sulfate (HS)

Syndecan-3

Kd (nM)

± (SEM)

Kd (nM)

± (SEM)

CCL2

508

32

94

20

CCL7

109

8

143

14

CXCL8

145

6

184

22