Fig. 4
From: Juvenile idiopathic arthritis associated with a mutation in GATA3
T helper cell differentiation and cytokine secretion. Ex vivo expression of cytokines from polarized Th1, Th2, Th17, and Th0 cell cultures. The expressed cytokines are IFNγ for Th1 cells, IL-5 and IL-13 for Th2 cells, and IL-17A for Th17 cells. IFNγ expression is shown from Th0 cells. PBMC cultures were prepared in biologic triplicate. Three PBMC collections are shown, with proband (sample 1) and sibling (collected 12 months after JIA diagnosis) and proband (sample 2) (collected 9 months after JIA diagnosis). Assays are n = 3 except proband (sample 2) Th0 is n = 2. Sibling and proband are compared. Mean and SEM are shown with *P < 0.05 and **P < 0.01