Table 2 Diagnostic performance of urine biomarkers in differentiating active LN from inactive LN compared to conventional markers
From: Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis
ALN vs ILN Linear regression | AUC | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
D-dimer | 0.63 | 8.15 | 100 | 35.6 | 93.2 | 29.4 |
Plasmin | 0.86*** | 2875 | 100 | 69.9 | 95.7 | 50.0 |
TF | 0.74*** | 4.86 | 60.5 | 85.0 | 88.9 | 34.7 |
TFPI | 0.77*** | 0.19 | 86.4 | 58.2 | 91.5 | 35.8 |
Positive anti-dsDNA | Â | Â | 40.0 | 66.7 | 84.9 | 22.6 |
Low complement | Â | Â | 56.3 | 61.9 | 82.1 | 27.1 |
LASSO regression | ||||||
 Plasmin+TFPI | 0.86*** | 0.76 | 83.3 | 86.4 | 95.0 | 63.2 |