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Table 2 Clinical characteristics of pSS patients included in the study

From: Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Patient no. Age Gender Anti-SSA* Anti-SSB* Focus score** GC FI score*** Schirmer test**** Saliva secretion ***** Dry mouth Dry eyes
1 48 F + + + + + +
2 59 F + + + + + +
3 52 F + + 8 + 1 + + + +
4 54 F + 1 2 + + +
5 60 F + + 3 + 1 + +
6 64 F + 0 1 + + + +
7 55 F + 0 2 + + + +
8 50 F + + + + +
9 35 F + + 3 + 0 + +
10 75 F + + + + +
  1. F female, GC germinal centres, FI fatty infiltration
  2. *Autoantibody production was assessed by ELISA
  3. **Values are the number of focal infiltrates/4mm2 tissue area containing > 50 mononuclear cells
  4. ***The degree of fatty infiltration was assessed and the sections were scored blindly, where no or little fatty infiltration = 0, moderate = 1, and prominent = 2
  5. ****Values are in mm/5 min; normal flow > 5 mm/5 min. ‘+’ indicates dryness and tear secretion ≤ 5 mm/5 min
  6. *****Values are in ml/15 min; normal flow > 1.5 ml/15 min. ‘+’ indicates dryness and unstimulated whole saliva secretion ≤ 1.5 ml/15 min