Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Table 5 Highly upregulated proteins in stimulated whole saliva of pSS patients

Number	Gene	Related protein*	Classification and function**
Non-SS vs. pSS
1	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	T cell activation and proliferation, upregulation of NF-kappa-B signalling
2	CD44	CD44 antigen	FOXP3 expression and regulatory T cell suppression, promotes tumour growth
3	B2MG	Beta-2-microglobulin	Antigen processing and presentation on MHC class I, innate immunity
Controls vs. pSS
1	SLUR1	Secreted Ly-6/uPAR-related protein 1	Acetylcholine receptor activity, cell migration and proliferation
2	B2MG	Beta-2-microglobulin	Antigen processing and presentation on MHC class I, innate immunity
3	CLUS	Clusterin	Innate immunity, modulates NF-kappa-B activity and TNF production

*The three most upregulated immunological proteins in whole saliva of pSS patients deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/)
**The classification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org)

ISSN: 1478-6362