Fig. 3

Mean trend over time: change in net ulcer burden. Digital ulcer net burden is defined as the total number of “active” and indeterminate digital ulcers at an assessment. LS, least squares; SE, standard error; CI, confidence interval. Estimates are from an ANCOVA model with terms for the treatment group and baseline digital net ulcer burden. Modified intent-to-treat population is defined as all participants randomized, receiving at least one dose of treatment, and having at least one post-baseline efficacy assessment