Skip to main content
Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Early treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study)

Fig. 2

Changes of mPAP over 6 months. No patients at baseline had a resting mPAP of ≥ 25 mmHg. After 6 months, 2 patients in the ambrisentan group developed a resting mPAP of > 25 mmHg. The dotted line indicates a resting mPAP of 25 mmHg. *: Two patients in the ambrisentan group had a resting PAWP of > 15 mmHg after 6 months; they were reclassified as PH due to left heart disease. #: Three patients in the placebo group developed a resting mPAP of ≥ 25 mmHg at month 6 with a resting PAWP of ≤ 15 mmHg; thus, they were diagnosed as having SSc-APAH after 6 months. The mean change of resting mPAP over 6 months in the ambrisentan group was − 1 ± 6.4 mmHg, and that in the placebo group was − 0.73 ± 3.59 mmHg. The changes between the two groups were not significantly different (p = 0.884). Ambrisentan did not significantly decrease the mPAP at rest over 6 months compared to placebo

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us