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Table 2 Univariate pairwise comparisons of mean biomarker levels between males and females in groups of those with identical radiological scores

From: Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

KL grade in each knee
(Nmale/Nfemale)
uCTX-II, mean, ng/mmol (SD) uCTX-I, mean μg/mmol (SD) Osteocalcin mean ng/mmol (SD)
Men Women p value for difference Men Women p value for difference Men Women p value for difference
0–2 (16/28) 153.8 (67.1) 269.8 (139.3) 0.24 1.39 (0.80) 1.68 (0.94) 0.98 24.02 (8.94) 22.80 (9.99) 0.99
1–2 (88/133) 200.4 (167.3) 275.9 (241.6) 0.01 1.44 (0.77) 2.18 (1.39) < 0.0001 21.37 (21.37) 24.83 (7.53) 0.01
2–2 (203/426) 200.5 (111.5) 284.9 (161.7) < 0.0001 1.30 (0.64) 2.03 (1.14) < 0.0001 20.64 (6.44) 25.31 (8.83) < 0.0001
1–3 (6/14) 261.3 (150.4) 261.9 (166.0) > 0.99 1.33 (1.11) 2.23 (0.91) 0.43 19.36 (10.26) 27.13 (8.12) 0.30
2–3 (63/149) 223.8 (96.2) 343.9 (186.8) < 0.0001 1.43 (0.76) 1.91 (1.08) 0.01 21.04 (6.60) 24.18 (8.16) 0.06
3–3 (11/69) 358.9 (267.3) 421.6 (245.0) 0.92 1.41 (0.70) 1.77 (0.84) 0.92 20.74 (4.37) 22.13 (6.37) 0.99
2–4 (8/10) 334.3 (179.8) 621.1 (347.2) 0.004 1.49 (0.65) 2.75 (1.11) 0.07 21.22 (6.94) 31.67 (12.85) 0.04
3–4 (2/13) 250.0 (193.7) 574.1 (383.4) 0.11 0.79 (0.12) 2.44 (0.76) 0.23 22.07 (5.19) 29.34 (11.46) 0.87
  1. KL Kellgren-Lawrence. Statistically significant differences between groups are highlighted in italics