Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

Table 2 Univariate pairwise comparisons of mean biomarker levels between males and females in groups of those with identical radiological scores

KL grade in each knee (N_male/N_female)	uCTX-II, mean, ng/mmol (SD)			uCTX-I, mean μg/mmol (SD)			Osteocalcin mean ng/mmol (SD)
KL grade in each knee (N_male/N_female)	Men	Women	p value for difference	Men	Women	p value for difference	Men	Women	p value for difference
0–2 (16/28)	153.8 (67.1)	269.8 (139.3)	0.24	1.39 (0.80)	1.68 (0.94)	0.98	24.02 (8.94)	22.80 (9.99)	0.99
1–2 (88/133)	200.4 (167.3)	275.9 (241.6)	0.01	1.44 (0.77)	2.18 (1.39)	< 0.0001	21.37 (21.37)	24.83 (7.53)	0.01
2–2 (203/426)	200.5 (111.5)	284.9 (161.7)	< 0.0001	1.30 (0.64)	2.03 (1.14)	< 0.0001	20.64 (6.44)	25.31 (8.83)	< 0.0001
1–3 (6/14)	261.3 (150.4)	261.9 (166.0)	> 0.99	1.33 (1.11)	2.23 (0.91)	0.43	19.36 (10.26)	27.13 (8.12)	0.30
2–3 (63/149)	223.8 (96.2)	343.9 (186.8)	< 0.0001	1.43 (0.76)	1.91 (1.08)	0.01	21.04 (6.60)	24.18 (8.16)	0.06
3–3 (11/69)	358.9 (267.3)	421.6 (245.0)	0.92	1.41 (0.70)	1.77 (0.84)	0.92	20.74 (4.37)	22.13 (6.37)	0.99
2–4 (8/10)	334.3 (179.8)	621.1 (347.2)	0.004	1.49 (0.65)	2.75 (1.11)	0.07	21.22 (6.94)	31.67 (12.85)	0.04
3–4 (2/13)	250.0 (193.7)	574.1 (383.4)	0.11	0.79 (0.12)	2.44 (0.76)	0.23	22.07 (5.19)	29.34 (11.46)	0.87

KL Kellgren-Lawrence. Statistically significant differences between groups are highlighted in italics

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