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Table 1 Univariate analysesa of predictive value of early MRI changes for later MRI and radiographic changes

From: Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis

   Change from baseline to month 1 Change from baseline to month 3
Change from baseline to month 12   RAMRIS synovitis RAMRIS osteitis RAMRIS erosions RAMRIS synovitis RAMRIS osteitis RAMRIS erosions
Total radiographic progressionb Estimate (SE); p value 0.044 (0.241); 0.856 0.007 (0.175); 0.971 1.431 (0.408); < 0.001 0.101 (0.188); 0.592 − 0.087 (0.138); 0.533 0.748 (0.252); 0.004
Radiographic erosion progression Estimate (SE); p value 0.039 (0.118); 0.743 0.031 (0.085); 0.718 0.638 (0.201); 0.002 0.087 (0.091); 0.339 − 0.013 (0.067); 0.853 0.455 (0.118); < 0.001
Radiographic JSN progression Estimate (SE); p value 0.010 (0.163); 0.951 − 0.024 (0.118); 0.837 0.792 (0.284); 0.007 0.015 (0.127); 0.905 − 0.074 (0.093); 0.434 0.295 (0.179); 0.104
   RAMRIQ synovitisc RAMRIQ osteitis RAMRIQ erosions RAMRIQ synovitisc RAMRIQ osteitis RAMRIQ erosions
RAMRIS erosion progression Estimate (SE); p value 0.0002 (0.0001); 0.004 0.287 (0.085); 0.001 – 0.0001 (0.0000); 0.008 0.354 (0.089); < 0.001 –
Total radiographic progression b Estimate (SE); p value 0.0004 (0.0001); < 0.001 0.930 (0.154); < 0.001 1.552 (0.846); 0.072 0.0002 (0.0001); 0.008 1.099 (0.222); < 0.001 − 0.498 (0.786); 0.529
Radiographic erosion progression Estimate (SE); p value 0.0001 (0.0000); 0.011 0.182 (0.092); 0.052 0.531 (0.417); 0.208 0.0001 (0.0000); 0.048 0.220 (0.123); 0.080 − 0.231 (0.382); 0.548
Radiographic JSN progression Estimate (SE); p value 0.0003 (0.0001); < 0.001 0.748 (0.089); < 0.001 1.017 (0.572); 0.080 0.0002 (0.0001); 0.012 0.879 (0.138); < 0.001 − 0.269 (0.533); 0.615
  1. aBased on univariate linear regression analysis
  2. bAssessed by mTSS
  3. cRAMRIQ synovitis is not normalised, where RAMRIQ osteitis and erosions are; as a result, the estimates and standard errors are low due to the scale
  4. JSN joint space narrowing, MRI magnetic resonance imaging, mTSS modified Total Sharp Score, RA rheumatoid arthritis, RAMRIQ automated quantitative RA MRI assessment system, RAMRIS RA MRI scoring system, SE standard error
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Arthritis Research & Therapy

ISSN: 1478-6362

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