Table 4 Performance of biomarkers to predict active SLE
From: Performance of cytokine models in predicting SLE activity
Biomarker | AUC | 95% CI | Cut-off point | Sensitivity | Specificity | LR+ | LR− |
|---|---|---|---|---|---|---|---|
C3 | 0.647 | 0.541–0.752 | < 0.90 g/l | 61.64% | 71.23% | 1.57 | 0.63 |
C4 | 0.612 | 0.500–0.724 | < 0.20 g/l | 47.06% | 63.10% | 1.48 | 0.68 |
Anti-dsDNA | 0.619 | 0.519–0.719 | > 100.0 IU/ml | 52.94% | 63.01% | 1.43 | 0.74 |
IFN-α | 0.622 | 0.523–0.720 | > 10.17 pg/ml | 50.98% | 59.80% | 1.68 | 0.70 |
MCP-1 | 0.707 | 0.616–0.799 | > 779.28 pg/ml | 66.67% | 67.12% | 2.02 | 0.49 |
IL-6 | 0.684 | 0.592–0.776 | > 5.44 pg/ml | 52.94% | 82.19% | 2.97 | 0.57 |
IL-8 | 0.754 | 0.663–0.844 | > 55.0 pg/ml | 64.00% | 82.43% | 3.38 | 0.44 |
IL-18 | 0.801 | 0.721–0.882 | > 50.0 pg/ml | 70.00% | 79.73% | 3.45 | 0.37 |