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Table 4 Proportion of patients experiencing radiographic progression (Δ SHS ≥ 3) within each time interval against categories of diseases activity (time-integrated standardized DAS28 scores) in the same period

From: Radiographic progression can still occur in individual patients with low or moderate disease activity in the current treat-to-target paradigm: real-world data from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

Time-integrated disease activity

0–6-month progression

6-month–1-year progression

1-year–2-year progression

2-year–3-year progression

No

Yes

No

Yes

No

Yes

No

Yes

Low (DAS28 < 3.2)

58 (77.3%)

17 (22.7%)

113 (83.1%)

23 (16.9%)

100 (77.5%)

29 (22.5%)

111 (84.1%)

21 (15.9%)

Moderate (DAS28 3.2–5.1)

79 (73.8%)

28 (26.2%)

20 (83.3%)

4 (16.7%)

15 (75.0%)

5 (25.0%)

8 (61.5%)

5 (38.5%)

High (DAS28 > 5.1)

7 (70.0%)

3 (30.0%)

2 (66.7%)

1 (33.3%)

0 (0.0%)

1 (100%)

1 (100%)

0 (0.0%)

Total

144 (75.0%)

48 (25.0%)

135 (82.8%)

28 (17.2%)

115 (76.7%)

35 (23.3%)

120 (82.2%)

26 (17.8%)