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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Fig. 3

Silencing lncRNA XIST suppresses the degradation of collagen in chondrocyte of OA. a Expression of lncRNA XIST in cells transfected with pGPU6/Neo-XIST-XIST or pCMV6-AC-GFP-XIST determined by RT-qPCR. b, c Expression of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, and type II collagen protein determined by Western blot analysis; * p < 0.05 vs. the sh-NC group (cells transfected with pGPU6/Neo); # p < 0.05 vs. the oe-NC group (cells transfected with pCMV6-AC-GFP); the measurement data were expressed as the mean ± standard deviation, which were analyzed by one-way analysis of variance; the experiment was repeated three times to obtain the mean value

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