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Table 3 Odds ratios for incident RA by elevated or normal levels of pre-RA ACPA using conditional logistic regression in the Nurses’ Health Studies

From: Asthma and elevation of anti-citrullinated protein antibodies prior to the onset of rheumatoid arthritis

 OR (95%CI) adjusted for matching factorsaMultivariableb OR (95%CI)
n = 96 outcomes from total n = 382
 No asthma1.00 (Ref)1.00 (Ref)
 Asthma3.70 (1.70, 8.05)3.57 (1.58, 8.04)
n = 188 outcomes from total n = 751
 No asthma1.00 (Ref)1.00 (Ref)
 Asthma0.93 (0.50, 1.72)0.87 (0.46, 1.61)
p for heterogeneity0.0060.004
  1. ACPA anti-citrullinated protein antibodies, CI confidence interval, OR odds ratio, RA rheumatoid arthritis
  2. aCases and controls were matched by age at index date, time from blood draw to index date, cohort, calendar year, fasting status, menopausal status, and postmenopausal hormone use
  3. bAdditionally adjusted for smoking (continuous pack-years), parental passive smoking (yes/no), ever lived with smoker (yes/no), and body mass index (continuous, kg/m2)