Fig. 3
Osteoarthritis development in SFZ-specific β-catenin-stabilized mice. a Safranin O staining and OARSI scores of mouse knee joints of Prg4-CreERT2;Ctnnb1-ex3fl/wt and Ctnnb1-ex3fl/wt mice 8 weeks after surgery. Tamoxifen induction was performed at 7 weeks. Each experimental group contained six biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test). b Immunostaining of Ctnnb1 and Prg4 in sham knee joints of Prg4-CreERT2;Ctnnb1-ex3fl/wt and Ctnnb1-ex3fl/wt mice 8 weeks after surgery. Scale bars, 20 μm