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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Fig. 3

Osteoarthritis development in SFZ-specific β-catenin-stabilized mice. a Safranin O staining and OARSI scores of mouse knee joints of Prg4-CreERT2;Ctnnb1-ex3fl/wt and Ctnnb1-ex3fl/wt mice 8 weeks after surgery. Tamoxifen induction was performed at 7 weeks. Each experimental group contained six biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test). b Immunostaining of Ctnnb1 and Prg4 in sham knee joints of Prg4-CreERT2;Ctnnb1-ex3fl/wt and Ctnnb1-ex3fl/wt mice 8 weeks after surgery. Scale bars, 20 μm

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