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Table 2 Difference in accumulation in immune complexes of different autoantibodies

From: Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Percentages in IC compared to those in sera

dsDNA, 2.26%

Histone, 2.97%

Rib P, 5.24%

PCNA, 12.9%

SSA/Ro52, 2.63%

SSA/Ro60, 2.27%

SSB/La, 2.59%

Sm, 0.788%

U1RNP, 1.60%

Histone, 2.97%

0.789

        

Ribosomal P, 5.24%

0.103

0.115

       

PCNA, 12.9%

< 0.001

< 0.001

0.001

      

SSA/Ro5, 2.63%

0.706

0.537

0.031

< 0.001

     

SSA/Ro60, 2.27%

0.636

0.405

0.040

< 0.001

0.835

    

SSB/La, 2.59%

0.912

0.851

0.082

< 0.001

0.708

0.533

   

Sm, 0.788%

0.002

0.001

< 0.001

< 0.001

< 0.001

0.004

0.001

  

U1RNP, 1.60%

0.263

0.166

0.027

< 0.001

0.330

0.507

0.196

0.009

 

Sm-U1RNP, 2.25%

0.446

0.409

0.061

< 0.001

0.630

0.733

0.454

0.006

0.794

Enrichment

dsDNA, 24.0

Histone, 29.7

Rib P, 59.7

PCNA, 149

SSA/Ro,52 28.0

SSA/Ro,60 21.4

SSB/La, 29.9

Sm, 7.29

U1RNP, 16.0

Histone, 29.7

0.895

        

Ribosomal P, 59.7

0.153

0.155

       

PCNA, 149

< 0.001

< 0.001

0.002

      

SSA/Ro5, 28.0

0.738

0.541

0.040

< 0.001

     

SSA/Ro60, 21.4

0.595

0.517

0.064

< 0.001

0.733

    

SSB/La, 29.9

0.978

0.876

0.103

< 0.001

0.719

0.578

   

Sm, 7.29

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

  

U1RNP, 16.0

0.292

0.211

0.040

< 0.001

0.381

0.168

0.192

0.005

 

Sm-U1RNP, 20.8

0.430

0.326

0.060

< 0.001

0.638

0.362

0.395

0.003

0.860

  1. Results are shown for the percentage of levels in IC as compared to conventional measurement in sera in the upper part and as enrichment after correction for total IgG concentrations in IC and sera in the lower part. Median values for the percentage in IC as compared to that in serum and enrichment factors are presented below each autoantibody name in the upper and lower parts, respectively. Differences between individual autoantibody specificities concerning percentage in IC (upper part) and enrichment factors (lower part) were compared pairwise with the Wilcoxon signed rank test, and significant differences are depicted in italics. The corresponding distributions are shown in Fig. 1c, d. Significant p values are presented in italics. Rib P ribosomal P