Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Table 3 Correlations between levels of C1q-binding IC on the one hand and autoantibody levels in sera or IC on the other hand

	All samples (n = 54)		Samples with serum levels > 40 U/mL of the corresponding autoantibody
Autoantibody	Serum	IC	Serum	IC
dsDNA	0.756 < 0.001	0.600 < 0.001	0.573 < 0.001	0.490 0.003
Histone	0.410 0.002	0.454 < 0.001	0.187 0.542	0.460 0.114
Ribosomal P	0.554 < 0.001	0.290 0.034	− 0.571 0.139	0.119 0.779
PCNA	0.466 < 0.001	0.170 0.219	NA	NA
SSA/Ro52	0.013 0.928	0.025 0.858	0.017 0.942	0.056 0.809
SSA/Ro60	0.055 0.694	− 0.042 0.765	− 0.015 0.937	− 0.314 0.098
SSB/La	− 0.039 0.780	0.096 0.492	0.291 0.415	0.380 0.278
Sm	0.358 0.008	0.291 0.033	0.064 0.852	0.353 0.287
U1RNP	0.280 0.040	0.270 0.049	− 0.002 0.995	0.271 0.211
Sm-U1RNP	0.322 0.018	0.264 0.054	0.426 0.254	0.460 0.213

Correlations and corresponding p values between variables were calculated by Spearman’s ρ. Significant correlations are presented in italics. NA not applicable (sample size = 1)

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