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Table 2 Ten proteins with the highest significance in multifactorial linear regression (constituting AGS) and presence of a link to the respective hallmark gene sets for pre-symptomatic individuals, RA patients, and controls compared two-by-two

From: Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Pre-symptomatic individuals vs. controls
 ProteinUp- or downregulatedaAdipogenesisInterferon alpha response 
3.74E−09#0.0439#2.08E−07#0.0371#
  TNF++ 
  PRR16   
  CSF2++ 
  CCDC85C   
  CASP8++ 
  IL33 + 
  FAM81A+  
  SELE++ 
  HTRA1++ 
  MMP10+  
Patients vs. Controls
 ProteinUp- or downregulatedaAdipogenesisHeme metabolism 
2.57E−13#0.0058#1.77E−10#0.0022#
  TNF++ 
  PRR16   
  S100A12++ 
  CSF2++ 
  CASP8++ 
  FAM81A++ 
  MMP10++ 
  HTRA1++ 
  SELE++ 
  ORM1, ORM2++ 
Pre-symptomatic individuals vs. patients
 ProteinUp- or downregulatedbApical junctionEpithelial-mesenchymal transitionTGF-β signaling
8.31E−13#0.0391#9.93E−43#0.0287#1.44E−09#0.0279#
  KCNB2+  
  S100A12++ 
  EPB41L5+++
  COL6A1+++
  ZNF618  +
  S100A12++ 
  TGFB3+++
  CCDC85C+ +
  CSF2+++
  DSC3+++
  SLC11A1   
  1. #Numbers below each hallmark title display enrichment p values: general NEA (left) and differential (right)
  2. An expression change-based comparison in apre-symptomatic individuals or RA patients vs. controls and bRA patients vs. pre-symptomatic individuals
  3. CASP8 caspase 8; CCDC85C coiled-coil domain containing 85C; COL6A1 collagen type VI alpha 1 chain; CSF2 colony-stimulating factor 2; DSC3 desmocollin 3; EPB41L5 erythrocyte membrane protein band 4.1 like 5; FAM81A family with sequence similarity 81 member A; HTRA1 HtrA serine peptidase 1; IL33 interleukin 33; KCNB2 potassium voltage-gated channel subfamily B member 2; MMP10 matrix metallopeptidase 10; ORM1, ORM2 orosomucoid 1,orosomucoid 2; PRR16 proline rich 16; S100A12 S100 calcium-binding protein A12; SELE selectin E; SLC11A1 solute carrier family 11 member 1; TGFB3 transforming growth factor beta 3; TNF tumor necrosis factor; ZNF618 zinc finger protein 618
  4. Protein included uniquely in one of three top ten protein lists