Fig. 8

Innate immune responses in the brains of FcγRIIB^−/−Yaa mice and effects of immunological changes on behavior. a Around the perivascular area of the meningeal space (hippocampal sulcus) where Iba-1⁺ myeloid cells accumulated, GFAP-positive reactive astrocytes and CD3⁺ cells were also increased. b MHC class I is upregulated in the vascular endothelium of FcγRIIB^−/−Yaa mice (hippocampus). c Results of the forced swim test and the tail-flick test in FcγRIIB^−/−Yaa mice and their control mice. a and b are representative images of n = 5 experiments of lupus models and controls. In c, symbols represent individual mice (n = 7) and horizontal lines indicate the mean and SEM. *P < 0.05 by Student’s t test