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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice

Fig. 8

Innate immune responses in the brains of FcγRIIB−/−Yaa mice and effects of immunological changes on behavior. a Around the perivascular area of the meningeal space (hippocampal sulcus) where Iba-1+ myeloid cells accumulated, GFAP-positive reactive astrocytes and CD3+ cells were also increased. b MHC class I is upregulated in the vascular endothelium of FcγRIIB−/−Yaa mice (hippocampus). c Results of the forced swim test and the tail-flick test in FcγRIIB−/−Yaa mice and their control mice. a and b are representative images of n = 5 experiments of lupus models and controls. In c, symbols represent individual mice (n = 7) and horizontal lines indicate the mean and SEM. *P < 0.05 by Student’s t test

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