Fig. 2

Takinib reduced the histological scores of CIA mice. Overall, takinib significantly reduced all joints summed scores compared to vehicle control (a). Reduction of inflammation (I), pannus (P), cartilage damage (CD), bone resorption (BR), and periosteal bone formation (PB) were seen in all joints of vehicle- and takinib-treated animals (b–f). n = 4 ± SEM/normal (vehicle) group, n = 9–12 ± SEM/vehicle disease control and takinib groups. *p < 0.05, **p < 0.01, ***p < 0.001 two-way ANOVA, Dunnett’s post hoc