Fig. 3

Takinib treatment reduces individual joint scores in knees. Knee from a vehicle control animal has marked inflammation (S) and moderate cartilage damage (large arrow) with minimal pannus (small arrow) and bone resorption (arrowhead) (a). Knee from an arthritic animal treated with 50 mg/kg of takinib has moderate inflammation (S) and cartilage damage (large arrow) with minimal pannus (small arrow) and bone resorption (arrowhead), as well as very minimal periosteal bone formation (not pictured) (b). Knee from a normal control animal has no lesions. S identifies synovium (c). Reduction of sum knees, inflammation (I), pannus (P), cartilage damage (CD), and bone resorption (BR) were seen in the knees of vehicle- and takinib-treated animals (d–h). n = 4 ± SEM/normal (vehicle) group, n = 9–12 ± SEM/vehicle disease control and takinib groups. *p < 0.05, **p < 0.01, ***p < 0.001 two-way ANOVA, Dunnett’s post hoc