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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Fig. 1

Histological and microstructural changes in the subchondral bone of the superior articular surface on the tibia. Representative images are shown from repeated experiments. a, b Safranin O/fast green- and H&E-stained sections showing the damaged region of the articular surface (indicated by black arrows; scale bar = 100 μm). c, d 2D and 3D images of the subchondral bone of the tibia showing the damaged region of the articular surface (indicated by white arrows; scale bar = 1 mm). e Semiquantitative results of the OARSI scoring system. f, g Bone quantification results of the subchondral bone of the tibia from healthy controls and OA patients, including the BV/TV (trabecular BV per TV) and BMD. (n = 4, *P < 0.05, **P < 0.01 vs CTL)

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