Fig. 1From: Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritisHistological and microstructural changes in the subchondral bone of the superior articular surface on the tibia. Representative images are shown from repeated experiments. a, b Safranin O/fast green- and H&E-stained sections showing the damaged region of the articular surface (indicated by black arrows; scale bar = 100 μm). c, d 2D and 3D images of the subchondral bone of the tibia showing the damaged region of the articular surface (indicated by white arrows; scale bar = 1 mm). e Semiquantitative results of the OARSI scoring system. f, g Bone quantification results of the subchondral bone of the tibia from healthy controls and OA patients, including the BV/TV (trabecular BV per TV) and BMD. (n = 4, *P < 0.05, **P < 0.01 vs CTL)Back to article page