Association of circulating microRNAs with prevalent and incident knee osteoarthritis in women: the OFELY study

Table 4 Differential expression of the miRNA level in the serum from controls and OA patients, analyzed by next-generation sequencing

Names	Log2 fold change	p value	FDR adjusted p value	Healthy average TPM	OA average TPM
hsa-miR-139-5p	0.73	0.0001	0.0434	90.1	143.3
hsa-miR-1299	− 3.38	0.0002	0.0434	12	0.8
hsa-miR-200a-3p	− 1.88	0.0003	0.0473	77.2	29.4
hsa-miR-129-5p	0.81	0.0022	0.1640	3.6	6.5
hsa-miR-429	− 1.43	0.0023	0.1640	5.5	2.5
hsa-miR-9-5p	0.83	0.0045	0.2410	3.2	6.1
hsa-miR-375	− 0.93	0.0065	0.2795	737	411.3
hsa-miR-139-3p	0.61	0.0072	0.2820	48.8	69.7
hsa-miR-200b-3p	− 1.18	0.0089	0.3193	28	15.7
hsa-miR-150-5p	0.72	0.0164	0.4619	173.6	252.6
hsa-miR-192-5p	− 1.03	0.0171	0.4619	1837.8	1161.9
hsa-miR-155-5p	0.52	0.0193	0.4907	64.9	87.5
hsa-miR-15b-3p	− 0.73	0.0247	0.5867	43.8	24.3
hsa-miR-1228-5p	0.78	0.0295	0.5918	4.9	8.7
hsa-miR-126-3p	0.38	0.0304	0.5918	3243.9	3976.7
hsa-miR-206	1.10	0.0338	0.6011	51.3	95.9
hsa-miR-199b-5p	− 0.57	0.0373	0.6011	29.9	18.6
hsa-miR-1246	0.67	0.0375	0.6011	29.9	46.9
hsa-miR-10b-5p	0.46	0.0428	0.6390	3848.4	5039.8
hsa-miR-642a-3p	0.69	0.0444	0.6405	4.5	7.2
hsa-miR-186-5p	− 0.45	0.0473	0.6405	777.7	534
hsa-miR-10a-5p	0.45	0.0493	0.6469	2613.1	3361.1

When we compared the OA vs healthy groups, 22 miRNAs showed differential expression (p < 0.05) between controls and OA patients. After Benjamini-Hochberg false discovery rate (FDR) correction, hsa-miR-139-5p, hsa-miR-1299, and hsa-miR-200a-3p remained significantly different between OA patients and controls (p < 0.05, FDR at 5%)

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