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Table 4 Differential expression of the miRNA level in the serum from controls and OA patients, analyzed by next-generation sequencing

From: Association of circulating microRNAs with prevalent and incident knee osteoarthritis in women: the OFELY study

NamesLog2 fold changep valueFDR adjusted p valueHealthy average TPMOA average TPM
hsa-miR-139-5p0.730.00010.043490.1143.3
hsa-miR-1299− 3.380.00020.0434120.8
hsa-miR-200a-3p− 1.880.00030.047377.229.4
hsa-miR-129-5p0.810.00220.16403.66.5
hsa-miR-429− 1.430.00230.16405.52.5
hsa-miR-9-5p0.830.00450.24103.26.1
hsa-miR-375− 0.930.00650.2795737411.3
hsa-miR-139-3p0.610.00720.282048.869.7
hsa-miR-200b-3p− 1.180.00890.31932815.7
hsa-miR-150-5p0.720.01640.4619173.6252.6
hsa-miR-192-5p− 1.030.01710.46191837.81161.9
hsa-miR-155-5p0.520.01930.490764.987.5
hsa-miR-15b-3p− 0.730.02470.586743.824.3
hsa-miR-1228-5p0.780.02950.59184.98.7
hsa-miR-126-3p0.380.03040.59183243.93976.7
hsa-miR-2061.100.03380.601151.395.9
hsa-miR-199b-5p− 0.570.03730.601129.918.6
hsa-miR-12460.670.03750.601129.946.9
hsa-miR-10b-5p0.460.04280.63903848.45039.8
hsa-miR-642a-3p0.690.04440.64054.57.2
hsa-miR-186-5p− 0.450.04730.6405777.7534
hsa-miR-10a-5p0.450.04930.64692613.13361.1
  1. When we compared the OA vs healthy groups, 22 miRNAs showed differential expression (p < 0.05) between controls and OA patients. After Benjamini-Hochberg false discovery rate (FDR) correction, hsa-miR-139-5p, hsa-miR-1299, and hsa-miR-200a-3p remained significantly different between OA patients and controls (p < 0.05, FDR at 5%)