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Table 1 Definitions of skin, kidney, and gastrointestinal involvement in IgAV

From: Predicting gastrointestinal and renal involvement in adult IgA vasculitis

 LocalizedVasculitic lesions present only below the waistline
 GeneralizedVasculitic lesions extending above the waistline
Renal involvement
 Hematuria> 5 red blood cells per high power field or red blood cells casts in the urinary sediment or hemoglobinuria ≥ 2+ on dipstick
 Macrohematuria> 1500 red blood cells/mm3 of urine
 Proteinuriaurine protein excretion > 300 mg/day
 Severe involvementnephrotic or nephritic syndrome with an acute worsening of the renal function, defined as either an increase in serum creatinine concentration or a decrease in the glomerular filtration rate estimated by the MDRD-4 > 25% from the patient’s baseline
GI involvementnew onset of diffuse abdominal pain or gastrointestinal bleeding
 Severe involvementbloody diarrhea, ileus or bowel perforation
  1. GI gastrointestinal, MDRD-4 Modification of Diet in Renal Disease, 4 variables