Table 1 Definitions of skin, kidney, and gastrointestinal involvement in IgAV
From: Predicting gastrointestinal and renal involvement in adult IgA vasculitis
Purpura | |
Localized | Vasculitic lesions present only below the waistline |
Generalized | Vasculitic lesions extending above the waistline |
Renal involvement | |
Hematuria | > 5 red blood cells per high power field or red blood cells casts in the urinary sediment or hemoglobinuria ≥ 2+ on dipstick |
Macrohematuria | > 1500 red blood cells/mm3 of urine |
Proteinuria | urine protein excretion > 300 mg/day |
Severe involvement | nephrotic or nephritic syndrome with an acute worsening of the renal function, defined as either an increase in serum creatinine concentration or a decrease in the glomerular filtration rate estimated by the MDRD-4 > 25% from the patient’s baseline |
GI involvement | new onset of diffuse abdominal pain or gastrointestinal bleeding |
Severe involvement | bloody diarrhea, ileus or bowel perforation |