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Table 3 Changes to model coefficients for the Nordic model to predict non-achievement of remission made during the fine-tuning process

From: Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort

VariableOriginal NordicFine-tuned Canada to predict non-achievement of remissionFine-tuned Canada to predict severe disease course
With lab testsNo lab testsWith lab testsNo lab tests
Constant (intercept)- 1.58 (- 0.70, -2.46)*0.240.17− 2.9− 2.8
Active joint count**0.04 (- 0.06, 0.14)0.160.150.220.21
ESR in mm/h0.03 (- 0.01, 0.07)- 0.01− 0.01
CRP > 10 mg/L- 0.07 (- 1.45, 1.31)0.120.08
Morning stiffness > 15 min1.16 (0.26, 2.06)0.420.380.23− 0.03
Physician global assessment0.16 (- 0.76, 1.08)0.150.14− 0.05− 0.06
ANA positive1.25 (0.25, 2.25)0.03− 0.56
HLA-B27 positive1.37 (0.29, 2.45)1.070.85
Ankle joint arthritis1.10 (0.12, 2.08)0.520.53− 0.70− 0.70
C-index (95% CI)0.68 (0.62, 0.74)0.74 (0.67, 0.80)0.74 (0.67, 0.81)0.79 (0.68, 0.91)0.79 (0.69, 0.89)
  1. *Numbers in parentheses are the 95% confidence interval
  2. **The Nordic cohort used the cumulative active joint count within 6 months of disease onset, while the ReACCh-Out cohort used the active joint count at baseline
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