Fig. 1

Subclinical colonic inflammation in ank/ank mice and C3FeB6-A/A^w-jwt/wt littermates at baseline. Top panel: Total pathology score (0–9) of 4–5-month-old ank/ank mice (n = 40) and C3FeB6-A/A^w-jwt/wt controls (n = 21). Student’s t test was used. Bottom panel: a Representative histopathological features of colons (× 200) (done by hematoxylin and eosin staining) from a ank/ank mouse with patchy colon inflammation (score 7). bank/ank mouse with no colon inflammation (score 0). c C3FeB6-A/A^w-jwt/wt mouse with a small focus of mucosal chronic inflammation (score 5), and d C3FeB6-A/A^w-jwt/wt mouse with normal colon (score 0)