Fig. 2
From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
Clinical and histological characteristics of lpsCAIA and mCAIA. Paws from BQ.Ncf1* (12–16-week-old male) mice after injecting 4 mg of Cab3 or anti-CII cocktail were assessed for arthritis development macroscopically. Cell infiltration and bone erosion were evaluated microscopically. a Mean arthritis score of lpsCAIA (n = 8–10) and b mean arthritis score of mCAIA (n = 12) after injection of antibody cocktail on day 0 and injection with LPS or mannan on days 5 and 60, as indicated by arrows. c H&E-stained paws scored for cell infiltration and bone erosion on a scale of 0–3. d Representative images of the paws on days 0, 9, 21, and 65 after injection with Cab3 in lpsCAIA and mCAIA were shown. e Histology of joint section (original mag. × 4). f Serum COMP concentration of Cab3-induced LPS-enhanced arthritis and anti-CII antibody-induced LPS-enhanced arthritis. g Serum COMP concentrations of Cab3-induced mannan-enhanced arthritis and anti-CII-induced mannan-enhanced arthritis. h, i Correlations between serum COMP to arthritis score in lpsCAIA and mCAIA were analyzed accordingly. The data shown as mean ± SEM (n = 9–12)